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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitionalcell carcinoma of bladder (BTCC) and normal epithelia of bladder was investigated, and the relationshipreverse transcription polymerase chain reaction (RT-PCR) in 30 cases of BTCC and 10 cases of normal bladderPRL-3 protein was checked by using immunohistochemistry in 30 cases of BTCC and 15 cases of normal bladderThe expression levels of PRL-1 and PRL-3 mRNA and protein were higher in BTCC than those in normal bladder

Keywords： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

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Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 384-387 doi: 10.1007/s11684-015-0405-z

Abstract:

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancerThe disease incidence of malignant bladder tumors in China is approximately 0.74%.report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladdercancer after bladder tumor resection.

Keywords： carcinoma     small cell     urinary bladder neoplasms     diagnosis    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro anddownstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cellproliferation, colony formation inhibition, and cell cycle arrest.For the first time, this study reveals that RFC4 is required for NPC cell proliferation and may play

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB     kidney cancer     cell proliferation    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cellidentified the correlation between p53 functional activation and its genotype in five different ESCC cellTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayinvestigated using Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cellThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: immunotherapies is the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladderBAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cellsWe conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer than wild-type BCG

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral squamous cellcarcinoma (OSCC) and tongue cancer cell line Tca8113, as well as their effects on each other.

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Keywords： tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leadingthe liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-basedpaper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-basedCritical issues that require consideration for the successful clinical translation of NK cell-based therapiesIf appropriately used and further optimized, NK cell-based therapies could dominate important roles in

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistanceGDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cellcarcinoma (ESCC) was still uncertain.

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 336-340 doi: 10.1007/s11465-010-0027-8

Abstract: A mathematical model for a bladder-urethra system can provide basic analysis for the disabled urethraBased on computational fluid dynamics (CFD), we developed a three-dimensional urodynamic bladder-urethrasystem, which includes bladder, bladder neck, prostate, and urethra.The realistic recirculation process of the urinary bladder during the physiologic voiding process inconjunction with a flow simulation through the female urinary bladder and urethra is presented.

Keywords： bladder-urethra system     stress urinary incontinence (SUI)     computational fluid dynamics (CFD)     urodynamics    

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract: efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma

Keywords： hepatocellular carcinoma     hepatitis     cytokine     stem cell     miRNA    

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Title Author Date Type Operation

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

Journal Article

Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Journal Article